Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory condition characterized by airflow limitation that is not fully reversible. Acute exacerbation of COPD (AECOPD) is a sudden worsening of respiratory symptoms, requiring an immediate change in management. Exacerbations are associated with increased morbidity, hospitalizations, and mortality, making timely and effective treatment crucial. This article provides a detailed approach to managing AECOPD using NICE (National Institute for Health and Care Excellence), British Thoracic Society (BTS), and Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. Definition of AECOPD An acute exacerbation of COPD is defined as a sustained worsening of baseline…